There are data for microcrystalline cellulose (E 460), methyl cellulose (E 461), hydroxypropyl cellulose (E 463) and sodium carboxymethyl cellulose (E 466), which were tested in mice, rats, hamsters and/or rabbits with oral dosing or via gavage. As regards microcrystalline cellulose (E 460) studies have been conducted in rats (dietary exposure) with a mixture including guar gum or sodium carboxymethylcellulose (E 466) (15% in either case). The NOAEL for both maternal and developmental toxicity were the highest experimental dosages, i.e. 4,500 mg/kg bw (for mixture with guar gum) and 4,600 mg/kg bw (for mixture with sodium carboxymethyl cellulose). Methyl cellulose (E 461) was examined in mice, rats, hamsters and rabbits. In two different studies, pregnant mice were exposed via gavage (vehicle corn oil) to a dose range of 16-1,600 mg methyl cellulose (E 461)/kg bw per day from day 6 to 15 of gestation, followed by a caesarean section at day 17 of gestation. In the first study, maternal toxicity (increase in mortality and reduced pregnancy rate in the survivors) as well as retarded ossification in fetuses were noticed at the highest tested level, pointing to a NOAEL of 345 mg methyl cellulose (E 461) mg/kg bw per day (the last but one highest dosage) in mice. In the second study, no maternal toxicity and fetal abnormalities were observed in mice exposed up to 700 mg methyl cellulose (E 461) mg/kg bw per day. Rat studies (n = 2) were performed in pregnant dams exposed via gavage (vehicle corn oil) to a dose range of 16-1,320 mg methyl cellulose (E 461) mg/kg bw per day from day 6 to 15 of gestation followed by a caesarean section at day 20. In the first study (0, 13, 51, 285 or 1,320 mg methyl cellulose (E 461)/kg bw per day) the highest tested dosage resulted in no maternal toxicity but also in increased incidence of extra centres of ossification in vertebrae of fetuses from high dose dams; in a second rat study, the incidence of such alteration slightly increased in fetuses from the highest dosed group (1,200 mg methyl cellulose (E 461)/kg bw per day). Based on the above results, a NOAEL of 285 mg methyl cellulose (E 461) mg/kg bw per day could be identified in rats. No maternal or fetal toxicity was detected in Golden hamsters exposed via gavage (vehicle corn oil) up to 1,000 mg methyl cellulose (E 461) mg/kg bw per day from day 6 to 10 of gestation followed by a caesarean section at day 20. The study on rabbits was discarded due to poor experimental design. The only relevant developmental toxicity study with hydroxypropyl cellulose (E 463) (dissolved in 1% gum arabic solution) was performed in pregnant rats exposed via gavage from day 7 to 17 of gestation to 0, 200, 1,000 or 5,000 mg/kg bw test item and some of them subjected to caesarean sections at day 20. No treatment-related adverse effects were detected in dams or in the examined fetuses. A number of dams were allowed to deliver and no clinical, behavioural or morphological changes were observed in the examined pups. Their reproductive ability was seemingly not affected and no abnormalities were found in the F1-derived fetuses. The in utero exposure to the highest dose (5,000 mg/kg bw per day) may be considered as the NOAEL of methyl cellulose (E 461) for this study. No mortality, and no adverse effects were observed on implantation or on fetal survival in pregnant mice or rats dosed via gavage with up to 1,600 mg sodium carboxymethyl cellulose (E 466)/kg bw per day.

10 reasons to use HPMC in gluten-free preparations:

1. Improved structure and consistency: Emulates the effect of gluten, providing elasticity and structure to the dough.
2. Moisture Retention: Helps keep gluten-free baked goods more moist and less dry.
3. Suitable for vegan and hypoallergenic diets: It is not derived from animal sources and does not contain common allergens such as gluten.
4. Stabilization: Useful for stabilizing emulsions and suspensions, improving the quality of preparations.
5. Gel formation: Take advantage of its ability to gel at high temperatures for different applications.
6. Thickening Properties: Acts as a thickener, improving the texture of food products.
7. Solubility in cold water: Facilitates incorporation into various recipes without the need for heating.
8. Compatibility: Works well with a wide range of food ingredients.
9. Shelf life: It can help extend the shelf-life of baked goods.
10. Flavor neutrality: It does not alter the flavors of the preparations, maintaining the desired taste.

10 reasons why it is advisable not to use HPMC in gluten-free preparations:

1. Cost: HPMC can be more expensive than other additives or ingredients.
2. Perception of over-processing: Some consumers may prefer less processed products or products with fewer additives.
3. Limitations in replicating sensory properties: It may not be able to exactly replicate all the properties of gluten.
4. Variable applicability: Not all gluten-free recipes benefit equally from the addition of HPMC.
5. Limited Availability: It is not always easily available in all markets or stores.
6. Experimentation needed: May require trial and error to get the proportions right.
7. Additive Dependence: Can lead to increased dependence on food additives.
8. Possible digestive reactions: Although rare, some people may have sensitivities to HPMC.
9. Effects on texture: It can influence the texture of some preparations in an undesirable way.
10. Negative consumer perceptions: Some consumers may have concerns about the use of food additives.

Hydroxypropyl methylcellulose plays a vital role in the formulation of vitamins and dietary supplements, helping to improve their stability, bioavailability and overall efficacy. As an ingredient with multiple applications, it remains a popular choice for manufacturers looking to improve product quality while meeting the preferences and dietary requirements of a broad consumer base.

Solubility: Soluble in water and some solvents, such as the appropriate proportion of ethanol/water, propanol/water, etc. The aqueous solution has surface activity. With high transparency and stable performance, the gel temperature of different specifications is different, the solubility changes with viscosity, the viscosity is lower and the solubility is greater. The performance of HPMC with different specifications has a certain difference. The dissolution of HPMC in water is not affected by the PH value.

MK30M FP、MT4031、MT5503