In a small study published in the European Journal of Nutrition in 2020, researchers examined the effects of several food additives, including titanium dioxide, along with artificial sweeteners and cleaning products by testing the fecal samples of 13 people. Titanium dioxide was among the samples that “induced significant shifts in microbiome community structure.” The growth of the bacterium species belonging to C. leptum, which has been shown to decrease in patients with inflammatory bowel disease, “significantly decreased in the presence of … titanium dioxide” among other additives and sweeteners tested.

How to Avoid It
What are the different forms of titanium dioxide in beauty and personal care products?
On the other hand, titanium dioxide is a synthetic mineral that is produced through a chemical reaction involving the mineral ilmenite or rutile. It is used in industries such as cosmetics, paint, and sunscreen as a whitening agent and pigment. The manufacturing process of titanium dioxide involves extracting the mineral from ores, purifying it through chemical processes, and then grinding it into a fine powder.
The applications in which it can be used are paints, inks, plastics, elastomers, paper, fillers, adhesives…
Manufacturers get titanium dioxide from minerals called brookite, rutile, and anatase. It's processed into a powder and refined to meet strict safety guidelines.
Lyophilized vitamins@P25TiO2NPs were obtained through the described methods with excellent reproducibility and yield: over 99% of initial P25TiO2NPs were functionalized.
