7. Hydroxypropyl Methylcellulose has better enzyme resistance than MC, and the possibility of enzymatic degradation of Hydroxypropyl Methylcellulose is less than that of MC.

For hydroxypropyl cellulose (E 463), the identified NOAEL corresponded to the highest dose 6,000 mg hydroxypropyl cellulose/kg bw per day (by gavage). The most relevant feeding studies with HPMC (E 464) were performed in rats which tolerated up to 10%, corresponding to 9,000 mg test item/kg bw per day. Rabbits tolerated up to 7,500 mg HPMC/kg bw per day administered via the diet (30 day exposure) and dogs up to 1,500 mg HPMC/kg bw per day, in either case being the highest tested dosages. More studies were conducted using sodium carboxy methylcellulose (E 466). The most relevant ones were conducted in rats, with NOAEL values ranging from 4,500 to 9,000 mg test item/kg bw per day (in all cases the highest dose tested). In these studies, some effects (caecum and colonic enlargement, urothelial hyperplasia, nephrocalcinosis, diffuse epithelial hyperplasia in the urinary bladder) were observed, however, not considered of toxicological concern: the findings in the gastrointestinal tract were considered to be a consequence of the accumulation of poorly absorbed water-soluble material and the findings in kidneys and urinary bladder were attributed to the up to fourfold higher concentration of sodium in the test diet compared with the basal diet. In one further study, rats were daily exposed (gavage) to doses equivalent to 0, 500, 2,500 or 5,000 mg/kg bw per day. Animals treated with ≥ 2,500 mg/kg bw per day had soft and pale faeces, which was attributed to the presence of test material and not considered of toxicological relevance. In the absence of any other adverse effects, also for this study, the identified NOAEL was the top dose (5,000 mg/kg bw per day).

HPMC is commonly used in building materials such as tile adhesives, plasters, and lightweight drywall. HPMC is generally more widely used and more expensive than methyl cellulose. However, HPMC has a number of advantages that are worth the price. These include better solubility, higher viscosity, better water retention, Ph stability and resistance to high temperatures. It is important to consider these differences when deciding which product is right for your needs.

Due to its water solubility, HPMC gel is often used in the formulation of sunscreen products to enhance their water resistance and overall performance.

How dangerous is HPMC?

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