TiO₂ comes in many different forms. However, only a few of these forms are considered food-grade (acceptable to be added to food). Many studies that raised concern about the safety of TiO₂, including the concern for genotoxicity, used forms of TiO₂ that are not considered acceptable for use in food and have different properties than food-grade TiO₂. Other studies did use food-grade TiO₂, but took steps to break the material down into smaller particles than what would normally be found in food.

Lithopone’s historical significance is further accentuated by the advancements and modifications that followed its inception. The 1874 patent by J.B. Orr, for instance, ushered in a new white pigment—Orr’s Zinc White. This innovation was attained by co-precipitating zinc sulfate and barium sulfide, followed by a calcination process. Further refinements marked the subsequent decades, the most notable being the enhancement of lightfastness achieved in the 1920s by introducing small amounts of cobalt salts before calcination.

The evidence also suggests that the toxicity of TiO₂ particles may be reduced when eaten as part of the diet. This is because proteins and other molecules in a person's diet can bind to the TiO₂ particles. This binding alters the physical and chemical properties of the particles, which influences how they interact with cells, tissues and organs.

Because of their small size, nanoparticles may have unique physical and chemical properties. These properties may cause them to interact with living systems differently than larger materials with the same chemical composition (also known as bulk materials).

Lithopone B301, Lithopone B311 powder, C.I. Pigment White 5, is a mixture of inorganic compounds, widely utilized as a white pigment. It is composed of a mixture of barium sulfate and zinc sulfide. These insoluble compounds blend well with organic compounds and confer opacity. Lithopone B301, Lithopone B311 powder is famous for the cheap production costs, greater coverage. Related white pigments include titanium dioxide, zinc oxide (zinc white), and zinc sulfide

Although barium sulfate is almost completely inert, zinc sulfide degrades upon exposure to UV light, leading to darkening of the pigment. The severity of this UV reaction is dependent on a combination of two factors; how much zinc sulfide makes up the pigments formulation, and its total accumulated UV exposure. Depending on these factors the pigment itself can vary in shade over time, ranging from pure white all the way to grey or even black. To suppress this effect, a dopant may be used, such as a small amount of cobalt salts, which would be added to the formulation. This process creates cobalt-doped zinc sulfide. The cobalt salts help to stabilize zinc sulfide so it will not have as severe a reaction to UV exposure.

Overall, Chinese anatase titanium dioxide stands out as a versatile and valuable material with a wide range of applications in various industries. Its unique properties make it a popular choice for use in pigments, sunscreen, environmental remediation, and energy conversion technologies. As research into this material continues to expand, we can expect to see even more innovative uses and advancements in the field of materials science.