favors the use of HPMC capsules as they allow us to manufacture supplements without additives like magnesium stearate. Manufacturing tablets requires glue, binders, fillers, and coating. With an HPMC capsule you can fill it with just the active ingredient, and thus minimize the number of additional ingredients required.

The majority of the available studies have been performed in rats, just few of them in rabbits and dogs. Among those meeting the current criteria for toxicological testing, the no observed adverse effect level (NOAEL) values for the different modified celluloses were identified most often corresponding to the highest tested level or changes in body or organ weights. For microcrystalline cellulose (E 460) the identified NOAELs in rats ranged from 3,769 mg/kg body weight (bw) per day to 9,000 mg/kg bw per day and in all cases corresponded to the highest levels of the test substance. For methyl cellulose (E 461), the dose level of 3% in rats (equivalent to 2,700 mg/kw bw per day) was selected as the NOAEL based on a decrease in body and organ weight displayed in male rats administered with the top additive level (10%, equivalent to 9,000 mg/kg bw per day and day).

Modified Types：

Ist HPMC vegan?

Pharmaceuticals: