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For research published in Archives of Toxicology in 2020, scientists fed one group of mice a solution containing titanium dioxide for one month, and compared it to those that did not receive the additive. They found “the richness and evenness of gut microbiota were remarkably decreased and the gut microbial community compositions were significantly changed” in the titanium dioxide group when compared with the control group. The tests also revealed that the titanium dioxide exposure could cause locomotor dysfunction, or mobility issues “by elevating the excitement of enteric neurons, which might spread to the brain via gut-brain communication by vagal pathway.” The researchers concluded: “These findings provide valuable insights into the novel mechanism of TiO2NP-induced neurotoxicity. Understanding the microbiota-gut-brain axis will provide the foundation for potential therapeutic or prevention approaches against TiO2NP-induced gut and brain-related disorders.”
Analyst Insight

rutile titanium dioxide for sale. Be sure to accurately calculate the amount of titanium dioxide you will need for your project to avoid running out mid-production. Additionally, buying in bulk may result in cost savings, so be sure to inquire about volume discounts from your supplier.
Source: Tranalysis and China Customs
In a statement sent to USA TODAY on Sunday, Justin Comes, vice president of research and development for Skittles maker Mars Wrigley North America, said the company couldn't comment on pending litigation – but that its use of titanium dioxide and all Mars Wrigley ingredients are safe and manufactured in compliance with strict quality and safety requirements established by food safety regulators, including the FDA.
Production[edit]
Lithopone, an alternative to titanium dioxide
Background
105°C volatile matter, %

Below 20% substitution, it is recommended to replace 1 kg of TiO2 with 1 kg of Lithopone.