Assessment of biocompatibility in eukaryotic cells
However, since it’s photosensitive — meaning it can stimulate free radical production — it’s usually coated in silica or alumina to prevent potential cell damage without reducing its UV-protective properties (7Trusted Source).
French researchers studied how and where E171 nanoparticles enter the bloodstream, first studying the route through pigs and then in vitro with human buccal cells, for a 2023 study published in the journal Nanotoxicology. The research showed that the nanoparticles absorbed quickly through the mouth and then into the bloodstream, before damaging DNA and hindering cell regeneration.