Of course, there are plenty of other materials that supplement capsules can be made from. HPMC is by far the most common, but bovine gelatine capsules are still used occasionally, or there are more unusual options, such as pullulan, which is made from a tapioca extract.
Solubility: Almost insoluble in absolute ethanol, ether, and acetone; swelling in cold
While HPMC is generally considered safe, some people may experience mild side effects, especially when consumed in high doses. These side effects may include gastrointestinal discomfort, bloating, or diarrhea. However, these effects are usually mild and short-lived and disappear once supplementation is stopped or the dose is reduced.
The HPMC capsule itself is made from a wood source, so is often described as natural. Of course the contents of the capsules you buy may or may not be from a natural source, but the shell itself will be.



What is HPMC?
11. What is related to the gel temperature of hydroxypropyl methyl cellulose?


