- In the sulfate process, the ore is first crushed and then heated with sulfuric acid. This reaction produces titanyl sulfate, which is subsequently treated with water to form titanium dioxide. The resulting precipitate is filtered, washed, dried, and calcined to produce the final product. One of the drawbacks of this method is the large amount of waste acid generated, which requires careful disposal to minimize environmental impact.
- In the factory, these purified pigments are then ground into a fine powder, a crucial step as the particle size directly impacts the intensity and opacity of the final color. This grinding process is typically done using specialized machinery, such as ball mills or bead mills, which meticulously reduce the particle size to achieve the desired consistency.
Should I be worried about the use of titanium dioxide in my toothpaste?
For a mini-review published in the journal Particle and Fibre Technology in 2021, scientists wanted to evaluate whether Ti02 particles contributed to the development and/or exacerbation of irritable bowel disease, and whether they altered the four elements of intestinal barrier function: the intestinal microbiota, the immune system, the mucus layer, and the epithelium. The breakdown of these four elements can contribute to autoimmune, neurological, inflammatory, infectious, and metabolic diseases. Following their review, the researchers concluded: “Data indicate that TiO2 is able to alter the four compartments of IBF and to induce a low-grade intestinal inflammation associated or not with pre-neoplastic lesions.”
It’s particularly useful in sunscreen as it has impressive UV resistance and helps block the sun’s UVA and UVB rays from reaching your skin (6Trusted Source).
Lithopone supplier: Synthesis method of lithopone

Fig. 9. Selected images of damaged skin treated with P25TiO2NPs 10% (left) and healthy skin treated with VitaminB2@P25TiO2NPs 10% (right).
In conclusion, the demand for dyes and pigments is on the rise, and having a reliable titanium dioxide factory like CAS 13463-67-7 is essential for meeting this demand. With its dedication to quality, sustainability, and innovation, CAS 13463-67-7 is well-positioned to continue serving the needs of its customers and the industry as a whole.
In its statement to USA TODAY, the FDA maintained that, in all post-approvals for food additives, our scientists continue to review relevant new information to determine whether there are safety questions and whether the use of such substance is no longer safe under the Federal Food, Drug, and Cosmetic Act.


Partial substitution of titanium dioxide in liquid paints
Lithopone 30% applied in masterbatch has maximum purity, good opacity and reasonable light fastness.
North America

They are the only two sunscreen ingredients classified by the FDA as safe and effective. And though titanium dioxide is usually used in mineral sunscreens in the form of nanoparticles, evidence suggests that few, if any, particles penetrate the skin.


